Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 8/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699947 | 0.89 | MCL1 (0.44) | KDM4EALDH1A1HSD17B10PARP1PARP2 | |
| SCHEMBL15477730 | 0.87 | MCL1 (0.43) | KDM4EALDH1A1PARP1PARP2CYP2D6 | |
| SCHEMBL2798590 | 0.81 | PIN1 (0.49) | PARP1PARP2ADRA1A | |
| SCHEMBL3462221 | 0.81 | PIN1 (0.49) | PARP1PARP2ADRA1A | |
| SCHEMBL3460627 | 0.81 | PIN1 (0.49) | PARP1PARP2ADRA1A | |
| SCHEMBL9371224 | 0.80 | CRBN (0.60) | — | |
| SCHEMBL19993861 | 0.76 | IKBKB (0.52) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL161548 | 0.76 | ADRA1A (0.51) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL28212021 | 0.76 | ADRA1A (0.51) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL6383642 | 0.76 | ADRA1A (0.51) | KDM4EALDH1A1MAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485678-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2012-08-15 | — | — | EP | claimed |