Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | MMP13 | P45452 | 3/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
| ▸ | MMP9 | P14780 | 2/20 | 0.65 |
| ▸ | MMP8 | P22894 | 2/20 | 0.65 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903560 | 0.91 | MAPT (0.60) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL28761270 | 0.83 | RAB9A (1.00) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL31357765 | 0.83 | RAB9A (1.00) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL30726440 | 0.83 | RAB9A (0.75) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL27040204 | 0.83 | RAB9A (0.75) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL11903481 | 0.81 | TRPV1 (0.72) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL3408914 | 0.80 | MAPT (0.47) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL11903492 | 0.79 | NPC1 (0.66) | RAB9ASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL31357888 | 0.79 | RAB9A (0.81) | RAB9AMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL3204662 | 0.78 | RAB9A (0.75) | RAB9AMAPTSMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |