Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 10/20 | 0.69 |
| ▸ | RAB9A | P51151 | 10/20 | 0.69 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13381573 | 0.87 | RAB9A (0.80) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL23012153 | 0.84 | GRM4 (0.73) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL6278943 | 0.81 | GRM4 (1.00) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL12764166 | 0.81 | RAB9A (1.00) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL18993406 | 0.78 | NPC1 (0.72) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL18027795 | 0.78 | NPC1 (1.00) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL7718028 | 0.78 | NPC1 (0.72) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL27903120 | 0.78 | RAB9A (1.00) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL2490566 | 0.78 | RAB9A (0.70) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL1520546 | 0.78 | MEN1 (0.70) | KMT2AMAPTMEN1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486042-A1 | BICYCLIC HETEROCYCLES AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-08-15 | — | — | EP | disclosed |