Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.70 |
| ▸ | NPC1 | O15118 | 12/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12764166 | 0.82 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL259290 | 0.81 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL18027795 | 0.80 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL13381573 | 0.80 | RAB9A (0.80) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL20068993 | 0.78 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL11903751 | 0.78 | KMT2A (0.70) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL6928827 | 0.78 | GRM5 (0.72) | — | |
| SCHEMBL1793750 | 0.77 | SORT1 (0.53) | KMT2AMEN1SORT1 | |
| SCHEMBL1452104 | 0.76 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL1798177 | 0.76 | GRM5 (0.53) | SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837250-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-06-23 | — | — | EP | claimed |
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | claimed |
| EP-2370424-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2011-10-05 | — | — | EP | disclosed |