Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 15/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11904793 | 0.91 | CHRM1 (0.56) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904620 | 0.91 | CHRM1 (0.77) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904522 | 0.91 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904820 | 0.91 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904771 | 0.90 | CHRM1 (0.57) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904800 | 0.89 | CHRM1 (0.58) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904796 | 0.89 | CHRM1 (0.56) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904633 | 0.87 | CHRM1 (0.54) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904763 | 0.86 | CHRM1 (0.63) | CHRM1CHRM2CHRM4CHRM3CHRM5 | |
| SCHEMBL11904732 | 0.86 | OPRM1 (0.54) | CHRM1CHRM2CHRM4CHRM3CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960389-B1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LTD (GB) | 2012-08-15 | — | — | EP | claimed |