Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 15/20 | 0.51 |
| ▸ | AKT1 | P31749 | 15/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14782279 | 0.93 | RPS6KB1 (0.59) | RPS6KB1AKT1 | |
| SCHEMBL2063243 | 0.92 | RPS6KB1 (0.49) | RPS6KB1AKT1TRPV3 | |
| SCHEMBL11904481 | 0.91 | RPS6KB1 (0.60) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2063706 | 0.91 | RPS6KB1 (0.53) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2063972 | 0.91 | RPS6KB1 (0.49) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2063990 | 0.88 | GPR119 (0.49) | RPS6KB1AKT1GPR119TRPV3AKT2 | |
| SCHEMBL2063729 | 0.88 | GPR119 (0.45) | RPS6KB1AKT1GPR119TRPV3AKT2 | |
| SCHEMBL11904365 | 0.87 | RPS6KB1 (0.48) | RPS6KB1AKT1 | |
| SCHEMBL2063679 | 0.86 | RPS6KB1 (0.51) | RPS6KB1AKT1GPR119TRPV3AKT2 | |
| SCHEMBL11904562 | 0.85 | RPS6KB1 (0.46) | RPS6KB1AKT1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358710-B1 | AKT AND P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2012-08-15 | — | — | EP | disclosed |
| US-8148387-B2 | AKT and P70 S6 kinase inhibitors | ELI LILLY AND COMPANY (US) | 2012-04-03 | — | — | US | disclosed |
| US-20100120801-A1 | AKT AND P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120801-A1 | AKT AND P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, MTOR | RPS6KB1 7/4885AKT1 17/4885GPR119 1116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.