Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063007 | 0.89 | EPHX2 (0.47) | PTPRBPTPN11STSMEN1KMT2A | |
| SCHEMBL311399 | 0.87 | EPHX2 (0.47) | PTPRBPTPN11STSMEN1KMT2A | |
| SCHEMBL3397674 | 0.81 | PTPRB (0.48) | PTPRBPTPN11STSMEN1KMT2A | |
| SCHEMBL12497672 | 0.80 | MT-CO2 (0.40) | KMT2AMAPT | |
| SCHEMBL3330234 | 0.78 | TACR1 (0.40) | — | |
| SCHEMBL29189288 | 0.77 | STS (0.54) | STSMEN1KMT2APTPN2PTPN1 | |
| SCHEMBL30066884 | 0.77 | STS (0.54) | STSMEN1KMT2APTPN2PTPN1 | |
| SCHEMBL13326726 | 0.77 | CCR5 (0.52) | PTPRBPTPN11CCR5KCNH2 | |
| SCHEMBL17367288 | 0.75 | STS (0.54) | PTPRBPTPN11STSMEN1KMT2A | |
| SCHEMBL10159468 | 0.75 | MEN1 (0.62) | STSMEN1KMT2ANPSR1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358710-B1 | AKT AND P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2012-08-15 | — | — | EP | disclosed |