SCHEMBL11904765

SCHEMBL11904765

Cn1nc(Cc2ccc(Cl)c(Oc3cc(Cl)cc(C#N)c3)c2F)n(C)c1=O

nearest known ligand 0.63

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.63
CYP2C9 P11712 3/20 0.53
CYP2C19 P33261 2/20 0.53
KCNH2 Q12809 4/20 0.45
BRD9 Q9H8M2 1/20 0.35
SLC22A12 Q96S37 1/20 0.33
HTR2A P28223 2/20 0.32
EPAS1 Q99814 3/20 0.32
VEGFA P15692 2/20 0.31
NPBWR1 P48145 1/20 0.31
MCHR1 Q99705 1/20 0.31
CYP2D6 P10635 1/20 0.31
SLC6A4 P31645 1/20 0.30
CRHR1 P34998 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11904809 0.95 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19KCNH2BRD9
SCHEMBL11904762 0.92 CYP3A4 (0.60) CYP3A4CYP2C9CYP2C19KCNH2BRD9
SCHEMBL11903899 0.90 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19KCNH2SLC22A12
SCHEMBL11904766 0.89 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19KCNH2BRD9
SCHEMBL1654901 0.87 CYP3A4 (0.55) CYP3A4CYP2C9CYP2C19KCNH2MAPT
SCHEMBL5915079 0.87 CYP3A4 (0.55) CYP3A4CYP2C9CYP2C19KCNH2MAPT
SCHEMBL11904807 0.86 CYP3A4 (0.54) CYP3A4CYP2C9CYP2C19KCNH2HTR2A
SCHEMBL4808573 0.86 CYP3A4 (0.84) CYP3A4CYP2C9CYP2C19KCNH2SLC22A12
SCHEMBL11904215 0.85 CYP3A4 (0.52) CYP3A4CYP2C9CYP2C19KCNH2HTR2A
SCHEMBL2345051 0.84 CYP3A4 (0.53) CYP3A4CYP2C9CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773790-B1 BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2012-08-15 EP claimed