Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPY4R | P50391 | 3/20 | 0.34 |
| ▸ | NPY1R | P25929 | 2/20 | 0.34 |
| ▸ | NPY2R | P49146 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL15110976 | 0.98 | OTC (0.39) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL27539177 | 0.92 | OTC (0.32) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL11905345 | 0.87 | PRCP (0.35) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL11905875 | 0.87 | SMN1; SMN2 (0.34) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL244720 | 0.84 | OTC (0.43) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL9754275 | 0.83 | OTC (0.50) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL5544125 | 0.83 | OTC (0.50) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL1821002 | 0.83 | OTC (0.50) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL5544129 | 0.83 | OTC (0.50) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL5312506 | 0.83 | OTC (0.50) | OTCNOS3NOS1NOS2DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9091700-B2 | Modified peptide substrate | MCMASTER UNIVERSITY (CA) | 2015-07-28 | — | — | US | claimed |
| US-20120208225-A1 | MODIFIED PEPTIDE SUBSTRATE | THE UNIVERSITY OF MELBOURNE (AU) | 2012-08-16 | — | — | US | claimed |
| US-10131932-B2 | Method for assaying a protease | MCMASTER UNIVERSITY | 2018-11-20 | — | — | US | disclosed |
| EP-3047033-B1 | METHOD FOR ASSAYING A PROTEASE | UNIV MCMASTER (CA) | 2018-08-22 | — | — | EP | disclosed |
| US-20160326569-A1 | METHOD FOR ASSAYING A PROTEASE | MCMASTER UNIVERSITY (CA) | 2016-11-10 | — | — | US | disclosed |
| EP-3047033-A1 | METHOD FOR ASSAYING A PROTEASE | Mcmaster University (CA) | 2016-07-27 | — | — | EP | disclosed |
| US-9091700-B2 | Modified peptide substrate | MCMASTER UNIVERSITY (CA) | 2015-07-28 | — | — | US | disclosed |
| WO-2015039211-A1 | METHOD FOR ASSAYING A PROTEASE | MCMASTER UNIVERSITY (CA) | 2015-03-26 | — | — | WO | disclosed |
| US-20120208225-A1 | MODIFIED PEPTIDE SUBSTRATE | THE UNIVERSITY OF MELBOURNE (AU) | 2012-08-16 | — | — | US | disclosed |