Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908142 | 0.86 | DHODH (0.49) | FFAR1FFAR4PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1711905 | 0.77 | PIM1 (0.53) | FFAR1FFAR4KMT2AMEN1MAPT | |
| SCHEMBL11906627 | 0.74 | MAP2K3 (0.50) | KMT2ANPC1MEN1KDM4ESMN1; SMN2 | |
| SCHEMBL1318082 | 0.73 | MAPT (0.50) | KMT2ANPC1MEN1APOBEC3GKDM4E | |
| SCHEMBL11907094 | 0.72 | PIK3CA (0.40) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL11906668 | 0.72 | PRKAB2 (0.44) | FFAR1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL11907402 | 0.71 | BTK (0.48) | FFAR4NPC1ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL11907358 | 0.71 | FFAR4 (0.46) | FFAR1FFAR4PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL11906508 | 0.70 | TRPV3 (0.54) | FFAR4DYRK1AALDH1A1 | |
| SCHEMBL11907806 | 0.69 | GRM2 (0.44) | FFAR1HSP90AA1HSP90AB1GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2014-09-04 | — | — | US | disclosed |
| US-8822497-B2 | PIM kinase inhibitors and methods of their use | NOVARTIS AG (CH) | 2014-09-02 | — | — | US | disclosed |
| EP-2132177-B1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | FFAR1 3373/4885FFAR4 3898/4885PRKAB2 411/4885 |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | FFAR1 3373/4885FFAR4 3898/4885PRKAB2 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.