Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724395 | 0.91 | ABCG2 (0.59) | ABCG2KDM4EMAPTABCB1MAPK14 | |
| SCHEMBL13319597 | 0.90 | ABCG2 (0.56) | ABCG2KDM4EMAPTABCB1MAPK14 | |
| SCHEMBL3793329 | 0.88 | ABCG2 (0.54) | ABCG2KDM4EMAPTABCB1MAPK14 | |
| SCHEMBL14201581 | 0.84 | ABCG2 (0.60) | ABCG2KDM4EMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL13351671 | 0.84 | ABCG2 (0.44) | ABCG2ABCB1 | |
| SCHEMBL1729223 | 0.83 | ABCG2 (0.58) | ABCG2KDM4EMAPTABCB1MAPK14 | |
| SCHEMBL13319599 | 0.82 | ABCG2 (0.55) | ABCG2KDM4EMAPTABCB1MAPK14 | |
| SCHEMBL1724296 | 0.82 | ABCG2 (0.56) | ABCG2KDM4EMAPTABCB1MAPK14 | |
| SCHEMBL3794082 | 0.80 | ABCG2 (0.53) | ABCG2KDM4EMAPTABCB1MAPK14 | |
| SCHEMBL1729245 | 0.79 | MEN1 (0.45) | ABCG2KDM4EMAPTABCB1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202793-A1 | RHO KINASE INHIBITORS | KADMON CORPORATION, LLC | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202793-A1 | RHO KINASE INHIBITORS | ROCK2, ROCK1, RHOA | ABCG2 1067/4885KDM4E 2220/4885MAPT 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.