Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729989 | 0.92 | ABCG2 (0.60) | ABCG2ROCK2MAPTKDM4EPRKD3 | |
| SCHEMBL3794472 | 0.88 | ABCG2 (0.56) | ABCG2ROCK2MAPTKDM4EPRKD3 | |
| SCHEMBL14202082 | 0.85 | ROCK2 (0.52) | ABCG2ROCK2MAPTKDM4EPRKD3 | |
| SCHEMBL11920150 | 0.84 | ABCG2 (0.58) | ABCG2ROCK2MAPTKDM4EL3MBTL1 | |
| SCHEMBL1721882 | 0.84 | ROCK2 (0.67) | ABCG2ROCK2PRKD3METPLK4 | |
| SCHEMBL1729223 | 0.81 | ABCG2 (0.58) | ABCG2ROCK2MAPTKDM4EL3MBTL1 | |
| SCHEMBL1729984 | 0.80 | ROCK2 (0.46) | ABCG2ROCK2MAPTKDM4EPRKD3 | |
| SCHEMBL1727990 | 0.80 | ABCG2 (0.58) | ABCG2ROCK2MAPTKDM4EPRKD3 | |
| SCHEMBL13319599 | 0.79 | ABCG2 (0.55) | ABCG2ROCK2MAPTKDM4EL3MBTL1 | |
| SCHEMBL3792568 | 0.78 | ABCG2 (0.57) | ABCG2ROCK2MAPTKDM4EPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |