Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 7/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954428 | 0.90 | CYP2C9 (0.47) | GNRHRHTR6CYP2C9TACR3 | |
| SCHEMBL2148933 | 0.90 | CYP2C9 (0.47) | GNRHRHTR6CYP2C9TACR3 | |
| SCHEMBL11917813 | 0.90 | CYP2C9 (0.47) | GNRHRHTR6CYP2C9TACR3 | |
| SCHEMBL11920557 | 0.85 | CCR5 (0.36) | HTR6CYP2C9TACR3SRCBTK | |
| SCHEMBL2832175 | 0.80 | GNRHR (0.41) | GNRHRHTR6SRCBTKLYN | |
| SCHEMBL2832475 | 0.80 | GNRHR (0.41) | GNRHRHTR6SRCBTKLYN | |
| SCHEMBL2832178 | 0.80 | GNRHR (0.41) | GNRHRHTR6SRCBTKLYN | |
| SCHEMBL11920581 | 0.79 | GNRHR (0.39) | GNRHRCYP2C9TACR3 | |
| SCHEMBL7914678 | 0.76 | POLB (0.36) | GNRHR | |
| SCHEMBL11920290 | 0.76 | GNRHR (0.36) | GNRHRCYP2C9TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242134-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2012-08-14 | — | — | US | disclosed |
| US-20100076016-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076016-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | KCNQ3, KCNK3, GRIK3 | GNRHR 1690/4885HTR6 545/4885CYP2C9 3674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.