Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | LONP1 | P36776 | 4/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11920719 | 0.89 | CNR1 (0.47) | SMN1; SMN2RAB9ANPC1CNR1HTT | |
| SCHEMBL3081564 | 0.87 | PSMB5 (0.53) | SMN1; SMN2RAB9ANPC1CNR1LONP1 | |
| SCHEMBL12180708 | 0.87 | PSMB5 (0.53) | SMN1; SMN2RAB9ANPC1CNR1LONP1 | |
| SCHEMBL464435 | 0.77 | PSMB5 (0.54) | SMN1; SMN2CNR1LONP1PSMB5PSMB11 | |
| SCHEMBL464439 | 0.76 | PSMB5 (0.53) | CNR1CYP1A2LONP1PSMB5PSMB11 | |
| SCHEMBL464428 | 0.75 | LONP1 (0.64) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL20095238 | 0.74 | CTSL (0.64) | SMN1; SMN2RAB9ANPC1HTTCTSL | |
| SCHEMBL11933676 | 0.74 | CTSL (0.64) | SMN1; SMN2RAB9ANPC1HTTCTSL | |
| SCHEMBL3752620 | 0.74 | PSMB5 (0.74) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL14302378 | 0.72 | PSMB11 (0.42) | SMN1; SMN2RAB9ANPC1CNR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212334-B1 | PROTEASOME INHIBITORS | MILLENNIUM PHARM INC (US) | 2012-08-15 | — | — | EP | disclosed |