Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.76 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.76 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.71 |
| ▸ | JAK2 | O60674 | 4/20 | 0.70 |
| ▸ | JAK3 | P52333 | 1/20 | 0.70 |
| ▸ | IKBKB | O14920 | 3/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.62 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.60 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467179 | 0.90 | ABL1 (0.69) | MAPK8MAPK10IKBKBABL1EGFR | |
| SCHEMBL13911505 | 0.88 | IKBKB (0.64) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL13911478 | 0.87 | MAPK8 (0.77) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL13049909 | 0.87 | PIK3CA (0.66) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL8246523 | 0.86 | MAPK8 (1.00) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL4383820 | 0.83 | JAK2 (1.00) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL8307949 | 0.82 | MAPK8 (0.63) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL1593016 | 0.82 | PRKCD (0.79) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL11924742 | 0.82 | IKBKB (0.63) | MAPK8MAPK10CAMK2DJAK2JAK3 | |
| SCHEMBL3753951 | 0.80 | IKBKB (0.67) | MAPK8MAPK10CAMK2DJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150313881-A1 | Therapeutic Methods for Type I Diabetes | UNIVERSITY OF MASSACHUSETTS | 2015-11-05 | — | — | US | disclosed |
| US-8501812-B2 | Therapeutic methods for type I diabetes | UNIVERSITY OF MASSACHUSETTS (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120208846-A1 | Therapeutic Methods For Type I Diabetes | UNIVERSITY OF MASSACHUSETTS | 2012-08-16 | — | — | US | disclosed |
| US-7897572-B1 | Theraputic methods for type I diabetes | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL (US) | 2011-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150313881-A1 | Therapeutic Methods for Type I Diabetes | MAPK9, IAPP, RNASE1 | MAPK8 25/4885MAPK10 12/4885CAMK2D 347/4885 |
| US-20120208846-A1 | Therapeutic Methods For Type I Diabetes | MAPK9, IAPP, RNASE1 | MAPK8 25/4885MAPK10 12/4885CAMK2D 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.