⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11928241 | 1.00 | — | — | |
| SCHEMBL2371656 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL2371628 | 0.97 | CYP2D6 (0.35) | — | |
| Hydrochloric Acid SCHEMBL2373048 | 0.97 | CYP2D6 (0.35) | — | |
| SCHEMBL12296978 | 0.81 | — | — | |
| Cadaverine Tartrate SCHEMBL14783295 | 0.80 | TSHR (0.40) | — | |
| SCHEMBL3188778 | 0.77 | LMNA (0.33) | — | |
| SCHEMBL5857345 | 0.73 | ALDH1A1 (0.41) | — | |
| SCHEMBL2519697 | 0.73 | — | — | |
| SCHEMBL16892845 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250361500-A1 | (S)-ENGINEERED OXYNITRILASE POLYPEPTIDES AND USES THEREOF | NOVARTIS AG (CH) | 2025-11-27 | — | — | US | claimed |
| EP-4536822-A1 | (S)-ENGINEERED OXYNITRILASE POLYPEPTIDES AND USES THEREOF | Novartis AG (CH) | 2025-04-16 | — | — | EP | claimed |
| US-11911371-B2 | Pyridine and pyrazine derivative for the treatment of chronic bronchitis | NOVARTIS AG (CH) | 2024-02-27 | — | — | US | claimed |
| US-20240058315-A1 | Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis | NOVARTIS AG (CH) | 2024-02-22 | — | — | US | claimed |
| WO-2023238078-A1 | (S)-ENGINEERED OXYNITRILASE POLYPEPTIDES AND USES THEREOF | NOVARTIS AG (CH) | 2023-12-14 | — | — | WO | claimed |
| CN-113891744-A | Pyridine and pyrazine derivatives for the treatment of CF, COPD and bronchiectasis | 诺华股份有限公司 | 2022-01-04 | — | — | CN | claimed |
| US-20210228554-A1 | Pyridine and Pyrazine Derivative for the Treatment of CF | NOVARTIS AG (CH) | 2021-07-29 | — | — | US | claimed |
| WO-2020250116-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | NOVARTIS AG (CH) | 2020-12-17 | — | — | WO | claimed |
| US-20200383960-A1 | Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis | NOVARTIS AG (CH) | 2020-12-10 | — | — | US | claimed |
| US-10117858-B2 | Pyridine and pyrazine derivative for the treatment of CF | NOVARTIS AG (CH) | 2018-11-06 | — | — | US | claimed |
| US-RE46757-E1 | Pyridine and pyrazine derivative for the treatment of CF | NOVARTIS AG (CH) | 2018-03-20 | — | — | US | claimed |
| EP-2845593-B1 | Pyridine and pyrazine derivative for the treatment of chronic obstructive pulmonary disease | NOVARTIS AG (CH) | 2017-01-25 | — | — | EP | claimed |
| US-9365552-B2 | Pyridine and pyrazine derivative for the treatment of CF | NOVARTIS AG (CH) | 2016-06-14 | — | — | US | claimed |
| EP-2547656-B1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | NOVARTIS AG (CH) | 2015-09-30 | — | — | EP | claimed |
| EP-2845593-A1 | Pyridine and pyrazine derivative for the treatment of chronic obstructive pulmonary disease | Novartis AG (CH) | 2015-03-11 | — | — | EP | claimed |
| US-20150045364-A1 | Pyridine and Pyrazine derivative for the Treatment of CF | NOVARTIS AG (CH) | 2015-02-12 | — | — | US | claimed |
| WO-2013038373-A1 | PYRIDINE AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2013-03-21 | — | — | WO | claimed |
| US-8247436-B2 | Pyridine and pyrazine derivative for the treatment of CF | NOVARTIS AG (CH) | 2012-08-21 | — | — | US | claimed |
| US-20260022366-A1 | ENGINEERED NITROALDOLASES | CODEXIS INC (US) | 2026-01-22 | — | — | US | disclosed |
| US-20110086847-A1 | THIADIAZOLE MODULATORS OF BETA ADRENERGIC RECEPTOR | AUSPEX PHARMACEUTICALS, INC. (US) | 2011-04-14 | — | — | US | disclosed |