Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 5/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL28875922 | 1.00 | SLC7A5 (0.52) | SLC7A5TP53LAP3SLC1A3SLC1A2 | |
| Threonine SCHEMBL917908 | 1.00 | SLC7A5 (0.52) | SLC7A5TP53LAP3SLC1A3SLC1A2 | |
| Threonine SCHEMBL8934992 | 1.00 | SLC7A5 (0.52) | SLC7A5TP53LAP3SLC1A3SLC1A2 | |
| Threonine SCHEMBL27586098 | 0.93 | SLC7A5 (0.50) | SLC7A5TP53LAP3SLC1A3SLC1A2 | |
| Threonine SCHEMBL6038228 | 0.89 | SLC7A5 (0.63) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL2702066 | 0.89 | SLC7A5 (0.63) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL18050157 | 0.89 | SLC7A5 (0.63) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL1480 | 0.89 | — | — | |
| Threonine SCHEMBL9461237 | 0.89 | SLC7A5 (0.63) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL117301 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118688315-A | Multichannel high-coverage synchronous quantification method for amino-containing and hydroxyl-containing compounds | 复旦大学 | 2024-09-24 | — | — | CN | claimed |
| CN-116735770-A | Synchronous quantitative detection method for multiple metabolites in biological sample | 复旦大学 | 2023-09-12 | — | — | CN | claimed |
| CN-118688315-A | Multichannel high-coverage synchronous quantification method for amino-containing and hydroxyl-containing compounds | 复旦大学 | 2024-09-24 | — | — | CN | disclosed |
| CN-116735770-A | Synchronous quantitative detection method for multiple metabolites in biological sample | 复旦大学 | 2023-09-12 | — | — | CN | disclosed |
| CN-116590359-A | Method for synthesizing adenosylcobalamin by in vitro cell-free multienzyme system | 中国科学院天津工业生物技术研究所 | 2023-08-15 | — | — | CN | disclosed |
| CN-109897810-B | De novo synthesis of vitamin B12Escherichia coli recombinant strain and construction method and application thereof | 中国科学院天津工业生物技术研究所 | 2020-06-09 | — | — | CN | disclosed |
| CN-106029083-B | Hydrophilic antibody-drug conjugates | 西雅图基因公司 | 2020-02-07 | — | — | CN | disclosed |
| CN-109897810-A | De novo formation vitamin B12Escherichia coli recombinant strain and its construction method and application | 中国科学院天津工业生物技术研究所 | 2019-06-18 | — | — | CN | disclosed |
| EP-2740739-B1 | AGROCYBE AEGERITA LECTIN AAL-2, AND ENCODING GENE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | WUHAN ALPHA-OMEGA BIOLOGY TECH CO LTD (CN) | 2016-12-28 | — | — | EP | disclosed |
| US-20140194367-A1 | AGROCYBE AEGERITA LECTIN AAL-2, AND ENCODING GENE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | WUHAN ALPHA-OMEGA BIOLOGY TECHNOLOGY CO., LTD(CN) (CN) | 2014-07-10 | — | — | US | disclosed |
| EP-2740739-A1 | AGROCYBE AEGERITA LECTIN AAL-2, AND ENCODING GENE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Wuhan Alpha-Omega Biology Technology Co., Ltd. (CN) | 2014-06-11 | — | — | EP | disclosed |
| US-20060030055-A1 | Methods and kits for separation and detection of proteins in biological samples | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2006-02-09 | — | — | US | disclosed |
| CN-1684582-A | Improved synthesis of polyanhydrides | UNIV RUTGERS (US) | 2005-10-19 | — | — | CN | disclosed |
| CN-1208344-C | Novel human cell endocytic regulatory protein, its coding sequence and use | IMMUNOLOGY INST SECOND MILITAR (CN) | 2005-06-29 | — | — | CN | disclosed |
| CN-1137261-C | Punctiform aerogenic monad prolyl endopeptidase and its preparation method and application | 中国科学院上海生物工程研究中心 | 2004-02-04 | — | — | CN | disclosed |
| EP-1311860-A2 | METHODS AND KITS FOR SEPARATION AND DETECTION OF PROTEINS IN BIOLOGICAL SAMPLES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2003-05-21 | — | — | EP | disclosed |
| CN-1388132-A | Cell death inducing protein and its coding sequence and use | SHANGHAI INST BIOCHEMISTRY (CN) | 2003-01-01 | — | — | CN | disclosed |
| US-20020072590-A1 | Methods and kits for separation and detection of proteins in biological samples | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-06-13 | — | — | US | disclosed |
| WO-2002016947-A2 | METHODS AND KITS FOR SEPARATION AND DETECTION OF PROTEINS IN BIOLOGICAL SAMPLES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-02-28 | — | — | WO | disclosed |
| CN-1299823-A | New human cell factor and its code sequence and use | SHANGHAI HUACHEN BIOLOG TECHNO (CN) | 2001-06-20 | — | — | CN | disclosed |