Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16909271 | 0.80 | KDM4E (0.39) | CYP1A2CYP3A4CYP2C19KDM4EGRM5 | |
| SCHEMBL11986180 | 0.78 | KDM4E (0.35) | CYP1A2CYP3A4CYP2C19KDM4ENQO1 | |
| SCHEMBL11986179 | 0.75 | KDM4E (0.33) | KDM4ENQO1RECQLMEN1KMT2A | |
| SCHEMBL11986177 | 0.75 | ALDH1A1 (0.40) | CYP1A2CYP2C19KDM4ERECQLMEN1 | |
| SCHEMBL11942295 | 0.75 | CYP1A2 (0.35) | CYP1A2CYP3A4CYP2C19KDM4ENQO1 | |
| SCHEMBL11986181 | 0.75 | KDM4E (0.33) | KDM4ENQO1RECQLMEN1KMT2A | |
| SCHEMBL12641373 | 0.72 | HTT (0.33) | KDM4ERECQLMEN1KMT2A | |
| SCHEMBL11942290 | 0.71 | EGLN2 (0.39) | CYP1A2CYP3A4CYP2C19NQO1GRM5 | |
| SCHEMBL8589238 | 0.70 | KMT2A (0.30) | KMT2A | |
| SCHEMBL29441272 | 0.70 | KMT2A (0.30) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9452984-B2 | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted) picolinates | DOW AGROSCIENCES LLC (US) | 2016-09-27 | — | — | US | disclosed |
| US-20150274669-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | DOW AGROSCIENCES LLC (US) | 2015-10-01 | — | — | US | disclosed |
| US-8993772-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993772-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140206881-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206881-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-8754231-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754231-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20120190859-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274669-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | CYP4F3, AFF4, CYP4F12 | CYP1A2 534/4885CYP3A4 12/4885CYP2C19 302/4885 |
| US-20120190859-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | CYP4F3, CYP4F12, AFF4 | CYP1A2 515/4885CYP3A4 13/4885CYP2C19 366/4885 |
| US-20140206881-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | CYP4F3, CYP4F12, AFF4 | CYP1A2 515/4885CYP3A4 13/4885CYP2C19 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.