Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NQO1 | P15559 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29239115 | 0.80 | TTR (0.32) | CYP1A2CYP2C19CYP3A4EGLN2GRM5 | |
| SCHEMBL31254236 | 0.80 | TTR (0.32) | CYP1A2CYP2C19CYP3A4EGLN2GRM5 | |
| SCHEMBL11986180 | 0.78 | KDM4E (0.35) | CYP1A2CYP2C19CYP3A4EGLN2KDM4E | |
| SCHEMBL14853156 | 0.75 | KDM4E (0.41) | CYP1A2CYP2C19CYP3A4EGLN2KDM4E | |
| SCHEMBL11942292 | 0.75 | MEN1 (0.38) | CYP1A2CYP2C19CYP3A4EGLN2KDM4E | |
| SCHEMBL11942290 | 0.75 | EGLN2 (0.39) | CYP1A2CYP2C19CYP3A4EGLN2GRM5 | |
| SCHEMBL14853157 | 0.75 | KDM4E (0.33) | EGLN2KDM4ERECQLMEN1KMT2A | |
| SCHEMBL11942294 | 0.75 | CYP1A2 (0.35) | CYP1A2CYP2C19CYP3A4KDM4EGRM5 | |
| SCHEMBL31214249 | 0.75 | AR (0.35) | KDM4E | |
| SCHEMBL16909271 | 0.72 | KDM4E (0.39) | CYP1A2CYP2C19CYP3A4EGLN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2667712-B1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2016-08-31 | — | — | EP | disclosed |
| US-8993772-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993772-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140206881-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206881-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-8754231-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754231-B2 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | DOW AGROSCIENCES, LLC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20120190859-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190859-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | CYP4F3, CYP4F12, AFF4 | CYP1A2 515/4885CYP2C19 366/4885CYP3A4 13/4885 |
| US-20140206881-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES | CYP4F3, CYP4F12, AFF4 | CYP1A2 515/4885CYP2C19 366/4885CYP3A4 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.