Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31254236 | 1.00 | TTR (0.32) | TTRALBEGLN2GRM5CYP1A2 | |
| SCHEMBL11986176 | 0.80 | TTR (0.34) | TTRALBEGLN2 | |
| SCHEMBL11942295 | 0.80 | CYP1A2 (0.35) | EGLN2GRM5CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL31258708 | 0.77 | KHK (0.37) | — | |
| SCHEMBL11942290 | 0.72 | EGLN2 (0.39) | EGLN2GRM5CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29238881 | 0.71 | TSHR (0.35) | — | |
| SCHEMBL23673410 | 0.69 | ALDH1A1 (0.32) | — | |
| SCHEMBL30599213 | 0.69 | ALDH1A1 (0.32) | — | |
| SCHEMBL18299185 | 0.69 | KDM4E (0.35) | EGLN2 | |
| SCHEMBL16909260 | 0.69 | XDH (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118251390-A | Heteroaryl linked analogs as MGLU5 negative allosteric modulators and methods of making and using the same | 范德比尔特大学 | 2024-06-25 | — | — | CN | disclosed |