Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | CASP1 | P29466 | 6/20 | 0.35 |
| ▸ | CASP7 | P55210 | 6/20 | 0.35 |
| ▸ | USP2 | O75604 | 6/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11946141 | 0.92 | POLB (0.39) | POLBSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL11946143 | 0.91 | POLB (0.39) | POLBSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL11946142 | 0.89 | POLB (0.37) | POLBSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL11946145 | 0.89 | CYP3A4 (0.34) | POLBLMNAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL11946148 | 0.87 | POLB (0.36) | POLBALDH1A1SLC2A1SLC2A3CYP3A4 | |
| SCHEMBL11946146 | 0.82 | MAPT (0.42) | POLBLMNAKMT2AALDH1A1CYP3A4 | |
| SCHEMBL11946149 | 0.81 | MAPT (0.35) | POLBALDH1A1SLC2A1SLC2A3CYP3A4 | |
| SCHEMBL17058088 | 0.80 | ALDH1A1 (0.35) | LMNAKMT2AALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL11946147 | 0.79 | POLB (0.37) | POLBLMNAALDH1A1CYP3A4MAPK1 | |
| SCHEMBL11946125 | 0.78 | POLB (0.40) | POLBSMN1; SMN2LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8232274-B2 | Pyridazinone derivatives useful as glucan synthase inhibitors | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20090170861-A1 | Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors | SCHERING CORPORATION AND ALBANY MOLECULAR RESEARCH, INC. | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170861-A1 | Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors | MAN2A1, GYS2, MANBA | POLB 1088/4885SMN1; SMN2 3911/4885LMNA 929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.