Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351053 | 0.79 | OPRM1 (0.50) | OPRM1OPRL1OPRK1HDAC3HDAC1 | |
| SCHEMBL5643705 | 0.77 | OPRM1 (0.48) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL10476543 | 0.77 | OPRM1 (0.48) | OPRM1OPRL1OPRK1OGFRL1HDAC3 | |
| SCHEMBL14618891 | 0.77 | OPRM1 (0.48) | OPRM1OPRL1OPRK1OGFRL1HDAC3 | |
| SCHEMBL18461217 | 0.77 | OPRM1 (0.48) | OPRM1OPRL1OPRK1OGFRL1 | |
| Hydrochloric Acid SCHEMBL1141355 | 0.76 | OPRM1 (0.47) | OPRM1OPRL1OPRK1OGFRL1HDAC6 | |
| Hydrochloric Acid SCHEMBL28043928 | 0.76 | OPRM1 (0.47) | OPRM1OPRL1OPRK1HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL28697040 | 0.76 | OPRM1 (0.47) | OPRM1OPRL1OPRK1OGFRL1HDAC3 | |
| Hydrochloric Acid SCHEMBL28226628 | 0.74 | OPRM1 (0.71) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL16867366 | 0.74 | OPRM1 (0.50) | OPRM1OPRL1OPRK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007774-B1 | THIAZOLYLDIHYDROINDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-25 | — | — | EP | disclosed |