Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14533695 | 0.90 | OPRM1 (0.43) | OPRM1OPRL1OPRK1PDE2ATSHR | |
| SCHEMBL14533621 | 0.90 | OPRM1 (0.43) | OPRM1OPRL1OPRK1PDE2ATSHR | |
| Ethylene SCHEMBL11096239 | 0.83 | OPRM1 (0.39) | OPRM1OPRL1OPRK1PDE2AALDH1A1 | |
| SCHEMBL19300837 | 0.82 | PDE2A (0.41) | OPRM1OPRL1OPRK1PDE2ATSHR | |
| SCHEMBL16870142 | 0.79 | PDE2A (0.40) | OPRM1OPRL1PDE2ATSHRALDH1A1 | |
| SCHEMBL16869995 | 0.77 | OPRM1 (0.45) | OPRM1OPRL1OPRK1SLC6A4SLC6A3 | |
| SCHEMBL8351053 | 0.76 | OPRM1 (0.50) | OPRM1OPRL1OPRK1HDAC1 | |
| SCHEMBL29071770 | 0.74 | PDE2A (0.51) | PDE2AALDH1A1LMNAHDAC1 | |
| SCHEMBL2793612 | 0.74 | OPRM1 (0.48) | OPRM1OPRL1OPRK1HDAC1SLC6A4 | |
| SCHEMBL11948469 | 0.74 | OPRM1 (0.48) | OPRM1OPRL1OPRK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087091-B1 | VAR2CSA-DRUG CONJUGATES | ZYMEWORKS INC (CA) | 2021-10-20 | — | — | EP | disclosed |
| US-20170246310-A1 | VAR2CSA-DRUG CONJUGATES | ZYMEWORKS INC. (CA) | 2017-08-31 | — | — | US | disclosed |
| US-20170029490-A1 | SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES | ZYMEWORKS INC. (CA) | 2017-02-02 | — | — | US | disclosed |
| WO-2015095952-A1 | VAR2CSA-DRUG CONJUGATES | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2015-07-02 | — | — | WO | disclosed |
| CN-1251523-A | Sulfonamide derivatives | LILLY CO ELI (US) | 2000-04-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246310-A1 | VAR2CSA-DRUG CONJUGATES | VARS1, GUSB, VAV1 | OPRM1 1589/4885OPRL1 1231/4885OPRK1 1739/4885 |
| US-20170029490-A1 | SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES | MPST, TPST2, SULT1A1 | OPRM1 2707/4885OPRL1 1421/4885OPRK1 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.