Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10319230 | 0.89 | DYRK1A (0.74) | DYRK1ADYRK1BPOLBPARP1L3MBTL1 | |
| SCHEMBL11950546 | 0.79 | DYRK1A (0.82) | DYRK1ADYRK1B | |
| SCHEMBL3632228 | 0.76 | PADI4 (0.56) | POLBPARP1L3MBTL1RXFP1BRD4 | |
| SCHEMBL21639567 | 0.75 | EGFR (0.54) | DYRK1ADYRK1BL3MBTL1RXFP1KDM4E | |
| SCHEMBL10318281 | 0.74 | DYRK1A (1.00) | DYRK1ADYRK1BKDM4EALDH1A1KMT2A | |
| SCHEMBL11950316 | 0.74 | DYRK1A (0.64) | DYRK1ADYRK1BPOLBTSHRKDM4E | |
| SCHEMBL11949573 | 0.73 | DYRK1A (0.56) | DYRK1ADYRK1BKDM4EALDH1A1MAPT | |
| SCHEMBL11950360 | 0.72 | DYRK1A (0.60) | DYRK1ADYRK1BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11952847 | 0.72 | DYRK1A (0.65) | DYRK1ADYRK1B | |
| SCHEMBL10321271 | 0.71 | DYRK1A (0.72) | DYRK1ADYRK1BALDH1A1MAPTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |