Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.82 |
| ▸ | DYRK1B | Q9Y463 | 19/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10324364 | 0.90 | DYRK1A (1.00) | DYRK1ADYRK1B | |
| SCHEMBL11952847 | 0.88 | DYRK1A (0.65) | DYRK1ADYRK1B | |
| SCHEMBL10323943 | 0.82 | DYRK1A (0.85) | DYRK1ADYRK1B | |
| SCHEMBL11949573 | 0.82 | DYRK1A (0.56) | DYRK1ADYRK1B | |
| SCHEMBL11951925 | 0.81 | DYRK1A (0.76) | DYRK1ADYRK1B | |
| SCHEMBL11950555 | 0.80 | DYRK1A (0.75) | DYRK1ADYRK1B | |
| SCHEMBL10324433 | 0.80 | DYRK1A (0.80) | DYRK1ADYRK1B | |
| SCHEMBL10324205 | 0.80 | DYRK1A (0.80) | DYRK1ADYRK1B | |
| SCHEMBL10324099 | 0.80 | DYRK1A (1.00) | DYRK1ADYRK1B | |
| SCHEMBL11950311 | 0.79 | DYRK1A (0.59) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |