Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.56 |
| ▸ | BRAF | P15056 | 12/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10323825 | 0.92 | DYRK1A (0.68) | DYRK1ADYRK1BBRAFPIK3CAMTOR | |
| SCHEMBL10323628 | 0.83 | DYRK1A (0.68) | DYRK1ADYRK1BALDH1A1 | |
| SCHEMBL11950546 | 0.82 | DYRK1A (0.82) | DYRK1ADYRK1B | |
| SCHEMBL10323700 | 0.81 | ALDH1A1 (0.43) | DYRK1ADYRK1BPIK3CAMTORPIK3CG | |
| SCHEMBL11950360 | 0.74 | DYRK1A (0.60) | DYRK1ADYRK1BKDM4EALDH1A1 | |
| SCHEMBL10322497 | 0.74 | POLB (0.50) | DYRK1ADYRK1BPIK3CAMTORPIK3CG | |
| SCHEMBL10323339 | 0.74 | DYRK1A (0.70) | DYRK1ADYRK1B | |
| SCHEMBL10323269 | 0.73 | DYRK1A (0.69) | DYRK1ADYRK1B | |
| SCHEMBL10323050 | 0.73 | DYRK1A (0.69) | DYRK1ADYRK1B | |
| SCHEMBL11950311 | 0.73 | DYRK1A (0.59) | DYRK1ADYRK1BKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |