Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272677 | 0.84 | CHRNB2 (0.46) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL14873858 | 0.83 | KMT2A (0.53) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL9908275 | 0.82 | HRH3 (0.46) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL30398570 | 0.81 | HRH3 (0.55) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL487617 | 0.81 | HRH3 (0.55) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL5025697 | 0.79 | KMT2A (0.47) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL5024697 | 0.78 | HRH3 (0.43) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL5025696 | 0.78 | KMT2A (0.41) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL5025701 | 0.78 | KMT2A (0.41) | HRH3KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL5024694 | 0.77 | KDM4E (0.42) | HRH3KMT2AMAPTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232273-B2 | Heterocyclic compounds and methods of use | GENENTECH, INC. (US) | 2012-07-31 | — | — | US | disclosed |