Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 18/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865225 | 0.85 | GRM2 (0.70) | GRM2 | |
| SCHEMBL8166648 | 0.71 | GRM2 (0.59) | GRM2 | |
| Jnj-40411813 SCHEMBL1035416 | 0.68 | GRM2 (1.00) | GRM2 | |
| SCHEMBL8160368 | 0.67 | GRM2 (0.77) | GRM2 | |
| SCHEMBL8154462 | 0.67 | GRM2 (0.48) | GRM2 | |
| SCHEMBL8167879 | 0.67 | GRM2 (0.78) | GRM2 | |
| SCHEMBL8157875 | 0.67 | GRM2 (0.52) | GRM2 | |
| SCHEMBL8156100 | 0.67 | GRM2 (0.63) | GRM2 | |
| SCHEMBL24967957 | 0.66 | HTR3A (0.47) | — | |
| SCHEMBL171886 | 0.66 | GRM2 (0.71) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994004-B1 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2012-08-01 | — | — | EP | disclosed |