Benzo[D]Thiazole

Benzo[D]Thiazole

SCHEMBL119610

NC1CCC1.c1ccc2scnc2c1

nearest known ligand 0.68

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.68
HSD17B10 Q99714 1/20 0.68
SPPL2A Q8TCT8 1/20 0.37
ESR1 P03372 1/20 0.36
DYRK1A Q13627 3/20 0.36
SMYD3 Q9H7B4 1/20 0.35
LTA4H P09960 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
KDM4E B2RXH2 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
HKDC1 Q2TB90 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HSD11B1 P28845 2/20 0.34
CLK1 P49759 2/20 0.34
DYRK1B Q9Y463 2/20 0.34
DPP4 P27487 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzo[D]Thiazole SCHEMBL28852645 0.88 ALDH1A1 (0.66) ALDH1A1HSD17B10SPPL2AESR1DYRK1A
Benzo[D]Thiazole SCHEMBL9752175 0.83 ALDH1A1 (0.76) ALDH1A1HSD17B10DYRK1ASMYD3SLC6A2
Benzo[D]Thiazole SCHEMBL31388426 0.82
Benzo[D]Thiazole SCHEMBL10847268 0.82
Benzo[D]Thiazole SCHEMBL451685 0.82
Benzo[D]Thiazole SCHEMBL900814 0.82 ALDH1A1 (1.00) ALDH1A1HSD17B10DYRK1ASLC6A2SLC6A4
Benzo[D]Thiazole SCHEMBL8430 0.82
Biphenyl SCHEMBL6933950 0.82 ALDH1A1 (0.68) ALDH1A1HSD17B10DYRK1ASLC6A2SLC6A4
Benzo[D]Thiazole SCHEMBL8169978 0.81 ALDH1A1 (0.86) ALDH1A1HSD17B10DYRK1AKDM4ENPC1
Benzo[D]Thiazole SCHEMBL49903 0.80 ALDH1A1 (0.95) ALDH1A1HSD17B10DYRK1ASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160089378-A1 TREATMENT OF OSTEOARTHRITIS PAIN ABBVIE INC (US) 2016-03-31 US disclosed
US-9186353-B2 Treatment of osteoarthritis pain ABBVIE INC. (US) 2015-11-17 US disclosed
US-8592467-B2 Benzothiazole cyclobutyl amine derivatives ABBVIE INC. (US) 2013-11-26 US disclosed
US-8592467-B2 Benzothiazole cyclobutyl amine derivatives ABBVIE INC. (US) 2013-11-26 US disclosed
EP-2386556-B1 Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands ABBVIE INC (US) 2013-10-23 EP disclosed
EP-2386556-B1 Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands ABBVIE INC (US) 2013-10-23 EP disclosed
EP-2424528-A2 TREATMENT OF OSTEOARTHRITIS PAIN Abbott Laboratories (US) 2012-03-07 EP disclosed
EP-1926729-B1 BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS ABBOTT LAB (US) 2011-12-21 EP disclosed
EP-2386556-A1 Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands Abbott Laboratories (US) 2011-11-16 EP disclosed
EP-2386556-A1 Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands Abbott Laboratories (US) 2011-11-16 EP disclosed
US-20100273778-A1 TREATMENT OF OSTEOARTHRITIS PAIN ABBOTT LABORATORIES (US) 2010-10-28 US disclosed
US-20090326222-A1 BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES ABBOTT LABORATORIES (US) 2009-12-31 US disclosed
US-7576110-B2 Benzothiazole cyclobutyl amine derivatives ABBOTT LABORATORIES (US) 2009-08-18 US disclosed
US-7576110-B2 Benzothiazole cyclobutyl amine derivatives ABBOTT LABORATORIES (US) 2009-08-18 US disclosed
CN-101312966-A Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands ABBOTT LAB (US) 2008-11-26 CN disclosed
CN-101312966-A Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands ABBOTT LAB (US) 2008-11-26 CN disclosed
EP-1926729-A1 BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS ABBOTT LABORATORIES (US) 2008-06-04 EP disclosed
WO-2007038074-A1 BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS ABBOTT LABORATORIES (US) 2007-04-05 WO disclosed
US-20070066588-A1 Benzothiazole cyclobutyl amine derivatives ABBVIE INC. 2007-03-22 US disclosed
US-20070066588-A1 Benzothiazole cyclobutyl amine derivatives ABBVIE INC. 2007-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160089378-A1 TREATMENT OF OSTEOARTHRITIS PAIN HRH3, HRH4, HRH2 ALDH1A1 1727/4885HSD17B10 2456/4885SPPL2A 4031/4885
US-20100273778-A1 TREATMENT OF OSTEOARTHRITIS PAIN HRH3, HRH4, HRH2 ALDH1A1 1727/4885HSD17B10 2456/4885SPPL2A 4031/4885
US-20090326222-A1 BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES HRH2, HRH4, HRH1 ALDH1A1 926/4885HSD17B10 2068/4885SPPL2A 4259/4885
US-20070066588-A1 Benzothiazole cyclobutyl amine derivatives HRH2, HRH4, HRH1 ALDH1A1 926/4885HSD17B10 2068/4885SPPL2A 4259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.