Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[D]Thiazole SCHEMBL28852645 | 0.88 | ALDH1A1 (0.66) | ALDH1A1HSD17B10SPPL2AESR1DYRK1A | |
| Benzo[D]Thiazole SCHEMBL9752175 | 0.83 | ALDH1A1 (0.76) | ALDH1A1HSD17B10DYRK1ASMYD3SLC6A2 | |
| Benzo[D]Thiazole SCHEMBL31388426 | 0.82 | — | — | |
| Benzo[D]Thiazole SCHEMBL10847268 | 0.82 | — | — | |
| Benzo[D]Thiazole SCHEMBL451685 | 0.82 | — | — | |
| Benzo[D]Thiazole SCHEMBL900814 | 0.82 | ALDH1A1 (1.00) | ALDH1A1HSD17B10DYRK1ASLC6A2SLC6A4 | |
| Benzo[D]Thiazole SCHEMBL8430 | 0.82 | — | — | |
| Biphenyl SCHEMBL6933950 | 0.82 | ALDH1A1 (0.68) | ALDH1A1HSD17B10DYRK1ASLC6A2SLC6A4 | |
| Benzo[D]Thiazole SCHEMBL8169978 | 0.81 | ALDH1A1 (0.86) | ALDH1A1HSD17B10DYRK1AKDM4ENPC1 | |
| Benzo[D]Thiazole SCHEMBL49903 | 0.80 | ALDH1A1 (0.95) | ALDH1A1HSD17B10DYRK1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160089378-A1 | TREATMENT OF OSTEOARTHRITIS PAIN | ABBVIE INC (US) | 2016-03-31 | — | — | US | disclosed |
| US-9186353-B2 | Treatment of osteoarthritis pain | ABBVIE INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-8592467-B2 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. (US) | 2013-11-26 | — | — | US | disclosed |
| US-8592467-B2 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2424528-A2 | TREATMENT OF OSTEOARTHRITIS PAIN | Abbott Laboratories (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-1926729-B1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20100273778-A1 | TREATMENT OF OSTEOARTHRITIS PAIN | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | US | disclosed |
| US-20090326222-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-7576110-B2 | Benzothiazole cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576110-B2 | Benzothiazole cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-08-18 | — | — | US | disclosed |
| CN-101312966-A | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBOTT LAB (US) | 2008-11-26 | — | — | CN | disclosed |
| CN-101312966-A | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBOTT LAB (US) | 2008-11-26 | — | — | CN | disclosed |
| EP-1926729-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LABORATORIES (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007038074-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LABORATORIES (US) | 2007-04-05 | — | — | WO | disclosed |
| US-20070066588-A1 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. | 2007-03-22 | — | — | US | disclosed |
| US-20070066588-A1 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160089378-A1 | TREATMENT OF OSTEOARTHRITIS PAIN | HRH3, HRH4, HRH2 | ALDH1A1 1727/4885HSD17B10 2456/4885SPPL2A 4031/4885 |
| US-20100273778-A1 | TREATMENT OF OSTEOARTHRITIS PAIN | HRH3, HRH4, HRH2 | ALDH1A1 1727/4885HSD17B10 2456/4885SPPL2A 4031/4885 |
| US-20090326222-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES | HRH2, HRH4, HRH1 | ALDH1A1 926/4885HSD17B10 2068/4885SPPL2A 4259/4885 |
| US-20070066588-A1 | Benzothiazole cyclobutyl amine derivatives | HRH2, HRH4, HRH1 | ALDH1A1 926/4885HSD17B10 2068/4885SPPL2A 4259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.