Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 1.00 |
| ▸ | HPGDS | O60760 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CDC25B | P30305 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | STAT6 | P42226 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005312 | 1.00 | PLK1 (1.00) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL31315042 | 0.86 | PLK1 (0.76) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL13520263 | 0.85 | PLK1 (0.72) | PLK1HPGDALDH1A1HIF1AGAA | |
| SCHEMBL5891933 | 0.85 | PLK1 (0.73) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL24433096 | 0.83 | PLK1 (0.71) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL24101354 | 0.82 | PLK1 (0.70) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL7842295 | 0.80 | PLK1 (0.67) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL4518755 | 0.80 | PLK1 (0.67) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL4469856 | 0.80 | CDC25B (0.78) | PLK1HPGDSMAPTKMT2AHPGD | |
| SCHEMBL6250609 | 0.79 | MAPT (0.77) | PLK1HPGDSMAPTKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220151962-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2022-05-19 | — | — | US | disclosed |
| US-20160011195-A1 | Method of Forming Fragment Ligated Inhibitors | UNIVERSITY OF SOUTH CAROLINA | 2016-01-14 | — | — | US | disclosed |
| US-20150315555-A1 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 | UNIVERSITY OF SOUTH CAROLINA | 2015-11-05 | — | — | US | disclosed |
| US-9175357-B2 | Fragment ligated inhibitors selective for the polo box domain of PLK1 | UNIVERSITY OF SOUTH CAROLINA (US) | 2015-11-03 | — | — | US | disclosed |
| US-20120202970-A1 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 | UNIVERSITY OF SOUTH CAROLINA (US) | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315555-A1 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 | PLK1, POLD1, CTDSP1 | PLK1 1/4885HPGDS 1808/4885MAPT 1916/4885 |
| US-20160011195-A1 | Method of Forming Fragment Ligated Inhibitors | PLK1, POLD1, POLR1E | PLK1 1/4885HPGDS 1867/4885MAPT 2043/4885 |
| US-20220151962-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | HDAC10, HDAC1, HDAC11 | PLK1 1289/4885HPGDS 2270/4885MAPT 1054/4885 |
| US-20120202970-A1 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 | PLK1, POLD1, CTDSP1 | PLK1 1/4885HPGDS 1808/4885MAPT 1916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.