Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.71 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | CDC25B | P30305 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13164717 | 0.88 | PLK1 (0.51) | PLK1KMT2AMAPTHPGDGAA | |
| SCHEMBL11962157 | 0.83 | PLK1 (1.00) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL2005312 | 0.83 | PLK1 (1.00) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL31315042 | 0.83 | PLK1 (0.76) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL5891933 | 0.82 | PLK1 (0.73) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL13184544 | 0.81 | PLK1 (0.63) | PLK1KMT2AMAPTHPGDGAA | |
| SCHEMBL18893131 | 0.80 | L3MBTL1 (0.74) | MAPTHPGDGAAALDH1A1HSD17B10 | |
| SCHEMBL24101354 | 0.80 | PLK1 (0.70) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL4469856 | 0.78 | CDC25B (0.78) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL7842295 | 0.78 | PLK1 (0.67) | PLK1HPGDSCDC25BKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220151962-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220151962-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | HDAC10, HDAC1, HDAC11 | PLK1 1289/4885HPGDS 2270/4885CDC25B 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.