Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.67 |
| ▸ | HPGDS | O60760 | 1/20 | 0.65 |
| ▸ | CDC25B | P30305 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | STAT6 | P42226 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 4/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518755 | 0.85 | PLK1 (0.67) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL4469856 | 0.85 | CDC25B (0.78) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL24101354 | 0.83 | PLK1 (0.70) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL535326 | 0.83 | PLK1 (0.65) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL4028585 | 0.83 | PLK1 (0.65) | PLK1HPGDSCDC25BMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL11445757 | 0.83 | CDC25B (0.76) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL14124722 | 0.81 | CDC25B (0.64) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL7560388 | 0.80 | CDC25B (0.88) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL3946697 | 0.80 | PLK1 (0.61) | PLK1HPGDSCDC25BMAPTKMT2A | |
| SCHEMBL4835983 | 0.80 | HPGDS (0.73) | PLK1HPGDSCDC25BMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454501-B1 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | SANKYO CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0839812-A1 | Preparation of benzylthiazolidine derivatives | Sankyo Company Limited (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5387596-A | Treating arteriosclerosis | SANKYO COMPANY, LIMITED (JP) | 1995-02-07 | — | — | US | disclosed |
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |