Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11963309 | 1.00 | PARP1 (0.51) | PARP1HDAC1MAPK8GPR119RET | |
| SCHEMBL11963125 | 0.84 | PARP1 (0.43) | PARP1HDAC1MAPK8GPR119RET | |
| SCHEMBL11963126 | 0.84 | PARP1 (0.43) | PARP1HDAC1MAPK8GPR119RET | |
| SCHEMBL11963802 | 0.83 | HDAC1 (0.43) | PARP1HDAC1MAPK8GPR119RET | |
| SCHEMBL11963801 | 0.83 | HDAC1 (0.43) | PARP1HDAC1MAPK8GPR119RET | |
| SCHEMBL11963223 | 0.79 | SLC6A7 (0.36) | PARP1HDAC1MAPK8CNR1 | |
| SCHEMBL11963070 | 0.79 | LRRK2 (0.53) | GPR119RETLRRK2 | |
| SCHEMBL11963443 | 0.78 | HDAC1 (0.43) | PARP1HDAC1MAPK8GPR119RET | |
| SCHEMBL11963537 | 0.77 | PARP1 (0.51) | PARP1HDAC1MAPK8GPR119RET | |
| SCHEMBL11963538 | 0.77 | PARP1 (0.51) | PARP1HDAC1MAPK8GPR119RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489663-A1 | Compounds as syk kinase inhibitors | Almirall, S.A. (ES) | 2012-08-22 | — | — | EP | disclosed |