Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 7/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902065 | 1.00 | GRM1 (0.46) | GRM1SLC6A7MMP2ADAMTS5AVPR1A | |
| SCHEMBL11963414 | 1.00 | GRM1 (0.46) | GRM1SLC6A7MMP2ADAMTS5AVPR1A | |
| SCHEMBL11963206 | 0.83 | GPR119 (0.50) | GRM1 | |
| SCHEMBL29182666 | 0.83 | GPR119 (0.50) | GRM1 | |
| SCHEMBL11963207 | 0.83 | GPR119 (0.50) | GRM1 | |
| SCHEMBL20210781 | 0.82 | HRH3 (0.46) | GRM1SLC6A7MMP2ADAMTS5AVPR1A | |
| SCHEMBL18916763 | 0.82 | HRH3 (0.46) | GRM1SLC6A7MMP2ADAMTS5AVPR1A | |
| SCHEMBL25232012 | 0.81 | AKR1C3 (0.45) | GRM1SLC6A7AVPR1AKDM4ESMO | |
| SCHEMBL25232011 | 0.81 | AKR1C3 (0.45) | GRM1SLC6A7AVPR1AKDM4ESMO | |
| SCHEMBL20140855 | 0.80 | GRM1 (0.67) | GRM1SLC6A7AVPR1ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489663-A1 | Compounds as syk kinase inhibitors | Almirall, S.A. (ES) | 2012-08-22 | — | — | EP | disclosed |