Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11963066 | 0.85 | ADAMTS5 (0.45) | GFERGRM1SLC6A7SMN1; SMN2GSK3B | |
| SCHEMBL21796983 | 0.78 | GBA1 (0.42) | LMNA | |
| SCHEMBL27167140 | 0.73 | ADAMTS5 (0.44) | GFERGRM1SLC6A7MMP2ADAMTS5 | |
| SCHEMBL15103173 | 0.73 | CHRM1 (0.39) | GFERGRM1SLC6A7SMN1; SMN2SMO | |
| SCHEMBL29849609 | 0.72 | PARP1 (0.38) | GRM1SLC6A7SMN1; SMN2MMP2ADAMTS5 | |
| SCHEMBL11963519 | 0.72 | MAP3K12 (0.38) | SLC6A7 | |
| SCHEMBL23297711 | 0.71 | ATR (0.44) | — | |
| SCHEMBL20424199 | 0.71 | ATR (0.44) | — | |
| SCHEMBL23297813 | 0.71 | ATR (0.44) | — | |
| SCHEMBL25385150 | 0.70 | GAA (0.44) | GFERGRM1SLC6A7SMN1; SMN2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489663-A1 | Compounds as syk kinase inhibitors | Almirall, S.A. (ES) | 2012-08-22 | — | — | EP | disclosed |