Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | STK10 | O94804 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.55 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | HCK | P08631 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13412328 | 0.89 | KDR (0.70) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL11966357 | 0.85 | KDR (0.77) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1227590 | 0.74 | KDR (0.75) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL17377931 | 0.74 | KDR (0.66) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1227092 | 0.74 | KDR (0.73) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1226894 | 0.73 | KDR (0.83) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1227648 | 0.73 | KDR (0.75) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL4047358 | 0.72 | MET (0.47) | — | |
| SCHEMBL1226645 | 0.72 | KDR (0.76) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1227392 | 0.72 | KDR (0.75) | KDRCYP3A4FGFR1KCNH2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778893-B2 | (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol metabolites | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120196814-A1 | (R)-1-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY)PROPAN-2-OL METABOLITES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-02 | — | — | US | disclosed |
| WO-2011044019-A1 | (R)-1-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY)PROPAN-2-OL METABOLITES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196814-A1 | (R)-1-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY)PROPAN-2-OL METABOLITES | CYP11B1, CYP11B2, CYP4B1 | KDR 1649/4885CYP3A4 13/4885FGFR1 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.