Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11954715 | 1.00 | TRPA1 (0.57) | TRPA1TRPV1KDM4ENPC1RAB9A | |
| SCHEMBL11895395 | 1.00 | TRPA1 (0.57) | TRPA1TRPV1KDM4ENPC1RAB9A | |
| SCHEMBL11895522 | 0.85 | TRPA1 (0.56) | TRPA1NPC1RAB9ACNR2ALDH1A1 | |
| SCHEMBL14638 | 0.82 | TRPA1 (0.64) | TRPA1KDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14637 | 0.80 | TRPA1 (0.51) | TRPA1KDM4EALDH1A1SLC6A3 | |
| SCHEMBL11967558 | 0.78 | TRPA1 (0.74) | TRPA1ALDH1A1LMNAESR1PGR | |
| SCHEMBL11966306 | 0.78 | TRPA1 (0.74) | TRPA1ALDH1A1LMNAESR1PGR | |
| SCHEMBL10827 | 0.78 | TRPA1 (0.74) | TRPA1ALDH1A1LMNAESR1PGR | |
| SCHEMBL11895629 | 0.78 | TRPA1 (0.74) | TRPA1ALDH1A1LMNAESR1PGR | |
| SCHEMBL11895419 | 0.78 | TRPA1 (0.74) | TRPA1ALDH1A1LMNAESR1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196894-A1 | NOVEL TRPA1 ANTAGONISTS | SCHERING CORPORATION | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196894-A1 | NOVEL TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885TRPV1 2/4885KDM4E 3915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.