Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | RECQL | P46063 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8406197 | 0.90 | HTRA2 (0.60) | HTRA2MEN1POLBKMT2ATNFRSF1A | |
| SCHEMBL8406200 | 0.84 | POLB (0.61) | HTRA2MEN1POLBKMT2ATNFRSF1A | |
| SCHEMBL5398104 | 0.81 | HTRA2 (1.00) | HTRA2MEN1POLBKMT2ATNFRSF1A | |
| SCHEMBL31358711 | 0.81 | MAPT (0.64) | MEN1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL11968679 | 0.79 | HTRA2 (1.00) | HTRA2MEN1POLBKMT2ATNFRSF1A | |
| SCHEMBL5991093 | 0.78 | POLB (0.57) | HTRA2MEN1POLBKMT2AMAPT | |
| SCHEMBL11151064 | 0.76 | MEN1 (0.72) | HTRA2MEN1POLBKMT2ATNFRSF1A | |
| SCHEMBL19652481 | 0.75 | XPA (0.82) | MEN1POLBKMT2AL3MBTL1USP2 | |
| SCHEMBL8404369 | 0.73 | HTRA2 (0.82) | HTRA2MEN1POLBKMT2ATNFRSF1A | |
| SCHEMBL5168014 | 0.73 | PIK3CG (0.78) | MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242122-B2 | Method and compounds for inhibition of cell death | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-08-14 | — | — | US | disclosed |