Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 3/20 | 0.82 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11968679 | 0.90 | HTRA2 (1.00) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL8406197 | 0.79 | HTRA2 (0.60) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL5398104 | 0.76 | HTRA2 (1.00) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL11968680 | 0.73 | HTRA2 (0.68) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL8406200 | 0.72 | POLB (0.61) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL8406199 | 0.71 | POLB (0.68) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL8406198 | 0.70 | HTRA2 (0.62) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL11151064 | 0.70 | MEN1 (0.72) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL8404370 | 0.66 | HTRA2 (1.00) | HTRA2POLBMEN1KMT2ATNFRSF1A | |
| SCHEMBL12218226 | 0.64 | MEN1 (0.71) | HTRA2POLBMEN1KMT2ATNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713981-B2 | Method and compounds for inhibition of cell death | UNIVERSITY OF CENTRAL FLORIDA (US) | 2010-05-11 | — | — | US | disclosed |
| US-20040171629-A1 | Method and compounds for inhibition of cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-09-02 | — | — | US | disclosed |