Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 9/20 | 0.41 |
| ▸ | IDH2 | P48735 | 4/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | PGK2 | P07205 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447907 | 1.00 | CYP3A4 (0.64) | CYP3A4TSHRP2RX7NOTUMIDH1 | |
| Bicarbonate SCHEMBL28211551 | 0.87 | CYP3A4 (0.55) | CYP3A4TSHRP2RX7PGK1PGK2 | |
| SCHEMBL28202386 | 0.87 | CYP3A4 (0.50) | CYP3A4TSHRP2RX7GABRA1GABRG2 | |
| SCHEMBL17141411 | 0.84 | CYP3A4 (0.68) | CYP3A4TSHRIDH1IDH2PGK1 | |
| SCHEMBL17141418 | 0.84 | CYP3A4 (0.68) | CYP3A4TSHRIDH1IDH2PGK1 | |
| SCHEMBL1274473 | 0.82 | CYP3A4 (0.46) | CYP3A4TSHRIDH1IDH2 | |
| SCHEMBL19047172 | 0.82 | CYP3A4 (0.59) | CYP3A4TSHRIDH1IDH2PGK1 | |
| SCHEMBL1690192 | 0.82 | CYP3A4 (0.59) | CYP3A4TSHRIDH1IDH2PGK1 | |
| SCHEMBL3295150 | 0.82 | P2RX7 (0.50) | CYP3A4TSHRP2RX7NOTUMIDH1 | |
| SCHEMBL24850052 | 0.79 | TSHR (0.55) | CYP3A4TSHRIDH1IDH2PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1044 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116041107-A | Gypsum coated slow release fertilizer for improving coating performance and preparation method and application thereof | 中国科学院南京土壤研究所 | 2023-05-02 | — | — | CN | claimed |
| WO-2022130403-A1 | NEW QUATERNARY AMMONIUM SALTS FOR TRIFLUOROMETHYLATION AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2022-06-23 | — | — | WO | claimed |
| CN-111517872-A | Gypsum coated slow release fertilizer and preparation method and application thereof | 中国科学院南京土壤研究所 | 2020-08-11 | — | — | CN | claimed |
| CN-111151248-A | Method for catalyzing heterocyclic halogen-containing organic matter hydrogenation dehalogenation by using supported metal oxide | 浙江大学 | 2020-05-15 | — | — | CN | claimed |
| US-10227303-B2 | Process for the preparation of halosubstituted trifluoromethylpyridines | SRF LIMITED (IN) | 2019-03-12 | — | — | US | claimed |
| CN-108017574-B | A kind of method of the chloro- 2,4,6- trifluoromethyl pyridine continuous production of fluroxypramide intermediate 3,5- bis- | 江苏中旗科技股份有限公司 | 2019-03-08 | — | — | CN | claimed |
| CN-107759513-A | Preparation method of 2-hydroxy-6-trifluoromethylpyridine | 山东汇盟生物科技有限公司 | 2018-03-06 | — | — | CN | claimed |
| CN-106866512-A | A kind of preparation method of the trifluoromethyl pyridine of 2 hydroxyl 6 | 常州沃腾化工科技有限公司 | 2017-06-20 | — | — | CN | claimed |
| WO-2015151116-A2 | PROCESS FOR PRODUCING 2-FLUORO-6-(TRIFLUOROMETHYL)PYRIDINE COMPOUNDS | JUBILANT LIFE SCIENCES LIMITED (IN) | 2015-10-08 | — | — | WO | claimed |
| CN-101945581-B | Herbicidal compounds | SYNGENTA LTD | 2015-01-07 | — | — | CN | claimed |
| EP-0966441-B1 | PROCESS FOR PREPARING 2-HYDROXY-6-TRIFLUOROMETHYLPYRIDINE | SYNGENTA LTD (GB) | 2002-12-11 | — | — | EP | claimed |
| EP-1109788-A1 | CHEMICAL PROCESS FOR PREPARING 2-HYDROXY-6-TRIFLUOROMETHYLPYRIDINE | Syngenta Limited (GB) | 2001-06-27 | — | — | EP | claimed |
| US-6143899-A | REACTING 2-FLUORO-6-TRIFLUOROMETHYLPYRIDINE OR A MIXTURE OF 2-FLUORO-6-TRIFLUOROMETHYLPYRIDINE AND 2-CHLORO-6-TRIFLUOROMETHYLPYRIDINE WITH AN ALKALI METAL HYDROXIDE, HEATING AND ACIDIFYING THE PRODUCT FORMED | ZENECA LIMITED (GB) | 2000-11-07 | — | — | US | claimed |
| WO-2000014068-A1 | CHEMICAL PROCESS FOR PREPARING 2-HYDROXY-6-TRIFLUOROMETHYLPYRIDINE | SYNGENTA LIMITED (GB) | 2000-03-16 | — | — | WO | claimed |
| EP-0966441-A1 | PROCESS FOR PREPARING 2-HYDROXY-6-TRIFLUOROMETHYLPYRIDINE | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | claimed |
| US-5973159-A | SOLVENT-FREE HYDROLYSIS FOR THE PREPARATION OF 2-HYDROXY-6-TRIFLUOROMETHYLPYRIDINE IN A SEALED VESSEL AT AN ELEVATED TEMPERATURE | ZENECA LIMITED (GB) | 1999-10-26 | — | — | US | claimed |
| WO-1998040355-A1 | PROCESS FOR PREPARING 2-HYDROXY-6-TRIFLUOROMETHYLPYRIDINE | ZENECA LIMITED (GB) | 1998-09-17 | — | — | WO | claimed |
| EP-0092117-B1 | PROCESS FOR PRODUCING CHLORONICOTINIC ACID COMPOUNDS | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1987-07-15 | — | — | EP | claimed |
| US-4563529-A | VAPOR PHASE CATALYTIC FLUORINATION OF PICOLINES OR LUTIDINES | ISHIHARA SANGYO KAISHA LTD. (JP) | 1986-01-07 | — | — | US | claimed |
| EP-0042696-B1 | PROCESS FOR PRODUCING TRIFLUOROMETHYLPYRIDINES | ISHIHARA SANGYO KAISHA LTD. (JP) | 1983-11-16 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227303-B2 | Process for the preparation of halosubstituted trifluoromethylpyridines | CYP4F3, CYP4F2, CYP4X1 | CYP3A4 8/4885TSHR 863/4885P2RX7 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.