Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11971099 | 0.76 | KDM4E (0.33) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11971170 | 0.72 | LRRK2 (0.30) | — | |
| SCHEMBL2690083 | 0.69 | POLB (0.35) | KDM4EPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27243496 | 0.68 | MAPK1 (0.38) | KDM4EALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL16003588 | 0.61 | PDE10A (0.45) | KDM4EALDH1A1GAAPDE10AMEN1 | |
| SCHEMBL826742 | 0.60 | SMN1; SMN2 (0.41) | KDM4EALDH1A1POLBSMN1; SMN2NPC1 | |
| SCHEMBL11971165 | 0.60 | BRD4 (0.33) | — | |
| SCHEMBL16561204 | 0.60 | PDE10A (0.44) | KDM4EALDH1A1PDE10ASMN1; SMN2MEN1 | |
| SCHEMBL12990152 | 0.59 | NPC1 (0.42) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16003611 | 0.59 | ALDH1A1 (0.38) | KDM4EALDH1A1POLBGAAAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598155-B2 | Imidazo[5,1-f][1,2,4]triazines for the treatment of neurological disorders | PFIZER INC. (US) | 2013-12-03 | — | — | US | disclosed |
| US-20120214791-A1 | Imidazo[5,1-f][1,2,4]Triazines for the Treatment of Neurological Disorders | PFIZER INC. | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214791-A1 | Imidazo[5,1-f][1,2,4]Triazines for the Treatment of Neurological Disorders | GRIK5, GRIN2C, BDNF | KDM4E 3588/4885ALDH1A1 545/4885POLB 2677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.