SCHEMBL1197772

SCHEMBL1197772

Cc1sc(-c2cccc(C(F)(F)F)c2F)nc1Cn1cc(C(=O)O)cn1

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MPL P40238 3/20 0.40
L3MBTL1 Q9Y468 1/20 0.38
PIM1 P11309 2/20 0.37
GRIN2B Q13224 8/20 0.36
KLKB1 P03952 3/20 0.35
KDR P35968 1/20 0.35
GRIN1 Q05586 2/20 0.35
GRIA2 P42262 1/20 0.35
GRIN2A Q12879 1/20 0.35
NTRK1 P04629 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30617732 1.00 MPL (0.40) MPLL3MBTL1PIM1GRIN2BKLKB1
SCHEMBL1198409 0.94 L3MBTL1 (0.37) MPLL3MBTL1PIM1GRIN2BKLKB1
SCHEMBL1198155 0.90 EIF4E (0.38) L3MBTL1KLKB1
SCHEMBL1198005 0.89 GRM2 (0.40) MPLL3MBTL1PIM1GRIN2BGRIN1
SCHEMBL12876089 0.88 L3MBTL1 (0.41) L3MBTL1GRIN2BKLKB1
SCHEMBL15418750 0.86 MPL (0.38) MPLPIM1GRIN2BKLKB1KDR
SCHEMBL1198150 0.83 GRM2 (0.40) L3MBTL1KLKB1
SCHEMBL1199366 0.82 MPL (0.40) MPLGRIN2BKLKB1NTRK1
SCHEMBL20278527 0.82 KLKB1 (0.48) MPLL3MBTL1KLKB1
SCHEMBL12876174 0.81 L3MBTL1 (0.41) L3MBTL1KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220128561-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GYANYLYL CYCLASE (SGC) BAYER AKTIENGESELLSCHAFT (DE) 2022-04-28 US claimed
EP-3911675-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GUANYLYL CYCLASE (SGC) Bayer Aktiengesellschaft (DE) 2021-11-24 EP claimed
CN-113330030-A Method for determining whether a subject is suitable for treatment with an agonist of soluble guanylate cyclase (sGC) 拜耳公司 2021-08-31 CN claimed
WO-2020148379-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GUANYLYL CYCLASE (SGC) BAYER AKTIENGESELLSCHAFT (DE) 2020-07-23 WO claimed
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-21 US claimed
EP-3291811-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) Bayer Pharma Aktiengesellschaft (DE) 2018-03-14 EP claimed
WO-2016177660-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-11-10 WO claimed
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELl SCHAFT (DE) 2016-06-09 US claimed
EP-3024455-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS Bayer Pharma Aktiengesellschaft (DE) 2016-06-01 EP claimed
EP-2531187-B1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS ADVERIO PHARMA GMBH (DE) 2015-08-12 EP claimed
WO-2015011086-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-01-29 WO claimed
US-8461348-B2 Heterocyclic derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-06-11 US claimed
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-02-07 US claimed
EP-2531187-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS Bayer Intellectual Property GmbH (DE) 2012-12-12 EP claimed
WO-2011095534-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-08-11 WO claimed
WO-2011095553-A1 SGC STIMULATORS OR SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-08-11 WO claimed
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-02-03 US claimed
EP-2264017-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2010-12-22 EP claimed
US-12427131-B2 Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2025-09-30 US disclosed
EP-2264017-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS PDE5A, PDE3B, PDE3A MPL 1638/4885L3MBTL1 4548/4885PIM1 1161/4885
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) PDE5A, PDE2A, PDE3A MPL 618/4885L3MBTL1 4426/4885PIM1 2371/4885
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS PDE5A, PDE3A, GMPS MPL 1189/4885L3MBTL1 4389/4885PIM1 2759/4885
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF PDE3B, PDE5A, PDE2A MPL 1170/4885L3MBTL1 4726/4885PIM1 1856/4885
US-12427131-B2 Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof MME, ECE1, REN MPL 2015/4885L3MBTL1 3762/4885PIM1 1163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.