3-Hydroxy-3-Methylglutaryl-Coenzyme A

3-Hydroxy-3-Methylglutaryl-Coenzyme A

SCHEMBL1198

CC(C)(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](C)(O)CC(=O)O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NAA50 Q9GZZ1 2/20 0.84
CHAT P28329 2/20 0.80
EP300 Q09472 4/20 0.79
KAT5 Q92993 2/20 0.79
AURKA O14965 2/20 0.79
KAT2B Q92831 1/20 0.79
CREBBP Q92793 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL29353902 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL20505754 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL12303241 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL29371268 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL4358590 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL219453 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL22277142 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL21067504 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL6382909 0.98 NAA50 (0.88) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL5497515 0.98 NAA50 (0.88) NAA50CHATEP300KAT5AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 16289 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636273-B2 Compositions for pathogenesis-directed therapy and treatments of skin diseases and disorders YALE UNIVERSITY (US) 2026-05-26 US claimed
US-20260125432-A1 MALTOSE DEPENDENT DEGRONS, MALTOSE-RESPONSIVE PROMOTERS, STABILIZATION CONSTRUCTS, AND THEIR USE IN PRODUCTION OF NON-CATABOLIC COMPOUNDS AMYRIS INC (US) 2026-05-07 US claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
WO-2026086805-A1 PCSK9 AND HMG-COA BICYCLIC COMPOUND, AND PREPARATION AND USE THEREOF 深圳信立泰药业股份有限公司 2026-04-30 WO claimed
EP-3730131-B1 TREATMENT OF BRAIN CANCER BY CONTINUOUS INFUSION OF COENZYME Q10 BPGBIO INC (US) 2026-04-22 EP claimed
EP-3863634-B1 LEVOKETOCONAZOLE FOR TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA STRONGBRIDGE DUBLIN LTD (IE) 2026-04-08 EP claimed
EP-4709477-A2 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF MICROVASCULATURE DYSFUNCTION AND RELATED DISEASES The Texas A&M University System (US) 2026-03-18 EP claimed
EP-3558298-B1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS MERCK SHARP & DOHME LLC (US) 2026-03-11 EP claimed
EP-3608338-B1 HUMAN ANTIBODIES TO THE GLUCAGON RECEPTOR REGENERON PHARMA (US) 2026-03-11 EP claimed
US-20260022407-A1 METHOD, ENZYME COMPOSITION, NUCLEIC ACID COMPOSITION, AND TRANSGENIC MICROORGANISM FOR PRODUCING ISOPRENE GLYCOL NATIONAL YANG MING CHIAO TUNG UNIV (TW) 2026-01-22 US claimed
WO-1993017557-A1 CHOLESTEROL LOWERING COMPOUNDS PRODUCED BY DIRECTED BIOSYNTHESIS MERCK & CO., INC. (US) 1993-09-16 WO claimed
EP-0547000-A1 Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor compound SANDOZ LTD. (CH) 1993-06-16 EP claimed
EP-0383432-B1 COENZYME Q10 WITH HMG-COA REDUCTASE INHIBITORS MERCK & CO. INC. (US) 1993-03-24 EP claimed
EP-0522431-A1 Phophorus-containing HMG-COA reductase inhibitors E.R. SQUIBB & SONS, INC. (US) 1993-01-13 EP claimed
WO-1991018903-A1 PYRROLOPYRIDAZINE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-12-12 WO claimed
US-5032602-A Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones BAYER AKTIENGESELLSCHAFT (DE) 1991-07-16 US claimed
US-4992462-A Inhibitor of HMG-CoA reductase BAYER AKTIENGESELLSCHAFT (DE) 1991-02-12 US claimed
US-4988711-A HMG-CoA reductare-inhibiting N-substituted N-amino-pyrroles BAYER AKTIENGESELLSCHAFT (DE) 1991-01-29 US claimed
EP-0383432-A1 Coenzyme Q10 with HMG-COA reductase inhibitors MERCK & CO. INC. (US) 1990-08-22 EP claimed
EP-0352575-A2 Substituted annealed pyrroles BAYER AG (DE) 1990-01-31 EP claimed