3-Hydroxy-3-Methylglutaryl-Coenzyme A

3-Hydroxy-3-Methylglutaryl-Coenzyme A

SCHEMBL21067504

CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@H]1OP(=O)(O)O)[C@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](C)(O)CC(=O)O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NAA50 Q9GZZ1 2/20 0.84
CHAT P28329 2/20 0.80
EP300 Q09472 4/20 0.79
KAT5 Q92993 2/20 0.79
AURKA O14965 2/20 0.79
KAT2B Q92831 1/20 0.79
CREBBP Q92793 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL29353902 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL20505754 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL12303241 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL29371268 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL4358590 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL1198 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL219453 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL22277142 1.00 NAA50 (0.84) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL6382909 0.98 NAA50 (0.88) NAA50CHATEP300KAT5AURKA
3-Hydroxy-3-Methylglutaryl-Coenzyme A SCHEMBL5497515 0.98 NAA50 (0.88) NAA50CHATEP300KAT5AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257381-A1 STEVIA REBAUDIANA KAURENOIC ACID HYDROXYLASE VARIANTS FOR HIGH EFFICIENCY PRODUCTION OF REBAUDIOSIDES EUAGORE, LLC 2025-08-14 US disclosed
US-12371677-B2 UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides CORN PRODUCTS DEVELOPMENT, INC. (US) 2025-07-29 US disclosed
US-20240174987-A1 UDP-DEPENDENT GLYCOSYLTRANSFERASE FOR HIGH EFFICIENCY PRODUCTION OF REBAUDIOSIDES CORN PRODUCTS DEVELOPMENT, INC. 2024-05-30 US disclosed
CN-115176023-A Amorpha-4, 11-diene 12-monooxygenase variants and uses thereof 阿米瑞斯公司 2022-10-11 CN disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257381-A1 STEVIA REBAUDIANA KAURENOIC ACID HYDROXYLASE VARIANTS FOR HIGH EFFICIENCY PRODUCTION OF REBAUDIOSIDES SPR, ME1, ADH7 NAA50 2685/4885CHAT 4621/4885EP300 3959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.