Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ulimorelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR known ✓ | Q92847 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ulimorelin SCHEMBL19586559 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL19958029 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL29375598 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL804500 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL12197514 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL18813859 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL19958027 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL12197513 | 1.00 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| Ulimorelin SCHEMBL29432592 | 0.98 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14092333 | 0.97 | GHSR (1.00) | GHSRCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130211045-A1 | MACROCYCLIC MODULATORS OF THE GHRELIN RECEPTOR | TRANZYME PHARMA INC. (CA) | 2013-08-15 | — | — | US | disclosed |
| EP-1648922-B9 | SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY | TRANZYME PHARMA INC (CA) | 2013-04-03 | — | — | EP | disclosed |
| EP-2319859-B1 | Spatially-defined macrocyclic compounds useful for drug discovery | TRANZYME PHARMA INC (CA) | 2013-03-27 | — | — | EP | disclosed |
| US-8334256-B2 | Pharmaceutical salts of macrocyclic modulators of the ghrelin receptor | TRANZYME PHARMA INC. (CA) | 2012-12-18 | — | — | US | disclosed |
| EP-1648922-B3 | SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY | TRANZYME PHARMA INC (CA) | 2012-08-15 | — | — | EP | disclosed |
| EP-2319859-A2 | Spatially-defined macrocyclic compounds useful for drug discovery | Tranzyme Pharma Inc. (CA) | 2011-05-11 | — | — | EP | disclosed |
| US-20090221689-A1 | Macrocyclic Modulators of the Ghrelin Receptor | TRANZYME PHARMA INC. | 2009-09-03 | — | — | US | disclosed |
| US-7452862-B2 | Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists | TRANZYME PHARMA, INC. (CA) | 2008-11-18 | — | — | US | disclosed |
| US-7452862-B2 | Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists | TRANZYME PHARMA, INC. (CA) | 2008-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221689-A1 | Macrocyclic Modulators of the Ghrelin Receptor | GHSR, GIPR, GHRHR | GHSR 1/4885CYP3A4 2928/4885CYP2D6 2748/4885 |
| US-20130211045-A1 | MACROCYCLIC MODULATORS OF THE GHRELIN RECEPTOR | GHSR, GIPR, GHRHR | GHSR 1/4885CYP3A4 2928/4885CYP2D6 2748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.