Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALML3 | P27482 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.40 |
| ▸ | BPTF | Q12830 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SDHA | P31040 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1393834 | 0.85 | CALML3 (0.59) | CALML3MAOAMAOBLMNAPTGS1 | |
| SCHEMBL12075276 | 0.84 | MAOA (0.40) | CALML3MAOABPTFMAOBLMNA | |
| SCHEMBL1393511 | 0.81 | CALML3 (0.59) | CALML3MAOAMAOBLMNAPTGS1 | |
| SCHEMBL3171878 | 0.81 | CALML3 (0.59) | CALML3MAOAMAOBLMNAPTGS1 | |
| SCHEMBL14386911 | 0.78 | BPTF (0.43) | CALML3MAOABPTFMAOBLMNA | |
| SCHEMBL14387394 | 0.76 | MAOA (0.38) | CALML3MAOABPTFMAOBLMNA | |
| SCHEMBL11983134 | 0.76 | MAOA (0.40) | CALML3MAOABPTFMAOBLMNA | |
| SCHEMBL1393541 | 0.76 | CALML3 (0.61) | CALML3MAOAMAOBLMNAPTGS1 | |
| SCHEMBL1393244 | 0.72 | MAOA (0.56) | CALML3MAOAMAOBLMNAPTGS1 | |
| SCHEMBL6302777 | 0.72 | CALML3 (0.74) | CALML3MAOAMAOBLMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656370-B1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB X PHARMACEUTICALS INC (US) | 2012-08-15 | — | — | EP | disclosed |