Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 6/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11988962 | 0.87 | SPPL2A (0.53) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11989387 | 0.77 | SPPL2A (0.52) | SPPL2ACYP3A4CCR5MEN1KMT2A | |
| SCHEMBL6526847 | 0.76 | BACE1 (0.51) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11989338 | 0.76 | MAPK1 (0.50) | SPPL2ACYP3A4TSHRCCR5MEN1 | |
| SCHEMBL11989390 | 0.75 | SPPL2A (0.46) | SPPL2ACYP3A4TSHRCCR5KMT2A | |
| SCHEMBL2584515 | 0.72 | BACE1 (0.51) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7462782 | 0.71 | BACE1 (0.56) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2582314 | 0.70 | BACE1 (0.59) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12067899 | 0.69 | CTRB1 (0.54) | CYP3A4TSHRALDH1A1CYP1A2CASP1 | |
| SCHEMBL12069802 | 0.69 | CTRB1 (0.54) | CYP3A4TSHRALDH1A1CYP1A2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43596-E1 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE LLC (US) | 2012-08-21 | — | — | US | disclosed |