Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.33 |
| ▸ | MLYCD | O95822 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3096219 | 0.87 | TRPV1 (0.54) | TRPV1DDR1MLYCDEPHX2NR1H4 | |
| SCHEMBL11998329 | 0.79 | TRPV1 (0.46) | TRPV1HTR2ASLC6A4KCNH2IDO1 | |
| SCHEMBL13707019 | 0.78 | TRPV1 (0.46) | TRPV1HTR2ASLC6A4KCNH2IDO1 | |
| SCHEMBL3094588 | 0.77 | TRPV1 (0.41) | TRPV1IDO1 | |
| SCHEMBL11910682 | 0.75 | TRPV1 (0.44) | TRPV1IDO1 | |
| SCHEMBL11910661 | 0.72 | TRPV1 (0.41) | TRPV1HTR2ASLC6A4IDO1 | |
| SCHEMBL18874188 | 0.70 | IDO1 (0.51) | TRPV1SLC6A4IDO1 | |
| SCHEMBL13530926 | 0.69 | NPC1 (0.38) | TRPV1EPHX2 | |
| SCHEMBL5968616 | 0.65 | MPO (0.43) | TRPV1MLYCDEPHX2NR1H4 | |
| SCHEMBL27649206 | 0.65 | CACNA1H (0.45) | TRPV1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489660-A1 | Methods for making central nervous system agents that are TRPV1 antagonists | Abbott Laboratories (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2009117626-A2 | METHODS FOR MAKING CENTRAL NERVOUS SYSTEM AGENTS THAT ARE TRPV1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-09-24 | — | — | WO | disclosed |