Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.38 |
| ▸ | TTBK1 | Q5TCY1 | 4/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | ADA | P00813 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11998940 | 0.87 | PAK4 (0.42) | HTR3ATTBK1PAK4PIKFYVETTBK2 | |
| SCHEMBL12001756 | 0.85 | TTBK1 (0.34) | TTBK1PAK4PIKFYVETTBK2MAP3K14 | |
| SCHEMBL12001488 | 0.82 | TTBK1 (0.36) | TTBK1PAK4PIKFYVETTBK2MAP3K14 | |
| SCHEMBL12001757 | 0.80 | TTBK1 (0.37) | TTBK1PAK4PIKFYVETTBK2MAP3K14 | |
| SCHEMBL12001662 | 0.80 | HTR3A (0.45) | HTR3ATTBK1PAK4PIKFYVEGRM4 | |
| SCHEMBL11998941 | 0.80 | HTR3A (0.41) | HTR3AGRM4RETMAP4K4ALDH1A1 | |
| SCHEMBL12001576 | 0.75 | TTBK1 (0.38) | TTBK1PAK4PIKFYVETTBK2MAP3K14 | |
| SCHEMBL12001492 | 0.73 | TTBK1 (0.35) | TTBK1PAK4PIKFYVETTBK2MAP3K14 | |
| SCHEMBL12001599 | 0.72 | MAP3K14 (0.38) | TTBK1PAK4PIKFYVETTBK2MAP3K14 | |
| SCHEMBL11970337 | 0.72 | PAK4 (0.44) | TTBK1PAK4PIKFYVETTBK2MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012123522-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | HTR3A 1884/4885TTBK1 915/4885PAK4 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.