Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.38 |
| ▸ | TTBK1 | Q5TCY1 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001688 | 0.94 | TTBK1 (0.36) | MAP3K14TTBK1ALDH1A1TSHR | |
| SCHEMBL12001592 | 0.94 | TTBK1 (0.36) | MAP3K14TTBK1ALDH1A1TSHR | |
| SCHEMBL12001597 | 0.94 | TTBK1 (0.36) | MAP3K14TTBK1ALDH1A1TSHR | |
| SCHEMBL12526051 | 0.88 | MAP3K14 (0.44) | MAP3K14TTBK1PAK4PIKFYVETTBK2 | |
| SCHEMBL12001599 | 0.86 | MAP3K14 (0.38) | MAP3K14TTBK1PAK4PIKFYVETTBK2 | |
| SCHEMBL12001703 | 0.86 | MAP3K14 (0.38) | MAP3K14TTBK1PAK4PIKFYVETTBK2 | |
| SCHEMBL11970471 | 0.86 | MAP3K14 (0.52) | MAP3K14PAK4PIKFYVE | |
| SCHEMBL12001493 | 0.84 | TTBK1 (0.39) | MAP3K14TTBK1PAK4PIKFYVETTBK2 | |
| SCHEMBL12001578 | 0.82 | TTBK1 (0.38) | MAP3K14TTBK1PAK4PIKFYVETTBK2 | |
| SCHEMBL12001701 | 0.82 | RAB9A (0.35) | TTBK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | MAP3K14 519/4885TTBK1 915/4885ALDH1A1 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.